Paris - Flyhalf Remi Tales has pulled out of France's Six Nations opener against England after failing to recover from an arm injury and has been replaced by Francois Trinh-Duc, the French federation said.
Fullback Jean-Marcellin Buttin will leave the squad after picking up an injury in a Top 14 game with his Clermont team on Saturday and will be replaced by Marc Andreu, the FFR added.
"Francois Trinh-Duc is back with us. Remi will heal and we hope he will be back on the turf very soon," France manager Philippe Saint-André said in a statement.
Montpellier's Tinh-Duc won his last cap in a Six Nations game against Scotland last year.
Saint-André will now have to choose between Jules Plisson, Trinh-Duc and Jean-Marc Doussain at flyhalf to face England next Saturday at the Stade de France.