Marcoussis - Julien Dupuy and Lionel Beauxis will pair up for France for the first time since 2009 after coach Philippe Saint-Andre named his team on Wednesday to face England in the Six Nations.
Scrumhalf Dupuy and flyhalf Beauxis replace Morgan Parra and Francois Trinh-Duc, the most used halfback pairing from 2008 to 2011 under former coach Marc Lievremont, in the key positions for Sunday's match at the Stade de France.
Having beaten Italy (30-12) and scraped a win against Scotland (23-17), France are still on course to win the tournament despite a 17-17 draw with Ireland last weekend.
This weekend's clash will be crucial to France's bid, but Saint-Andre believes Dupuy and Beauxis could be key.
"They know each other well because they've played together as halfbacks at Stade Francais," Saint-Andre told reporters on Wednesday.
"It's a strategic choice on my part. England are the team that occupy the field of play the most, especially away from home.
"It's also because during our first three games we struggled to really get going, and we had trouble getting out of our own half during the first 20 minutes."
Dupuy and Beauxis, who played at Stade Francais from 2009 to 2011, will be the third halfback pairing used by Saint-Andre in four matches.
Trinh-Duc had previously been paired with scrumhalf Dimitri Yachvili, who left the squad due to injury on February 9 and has not been recalled despite making an impressive return to competition with Biarritz in the Top 14.
Saint-Andre meanwhile has kept faith with his two centres from Clermont, Wesley Fofana and Aurelien Rougerie, his entire pack and the trio of backs in Clement Poitrenaud, Vincent Clerc and Julien Malzieu.
After Sunday's match France's Six Nations campaign concludes on March 17 in Cardiff against Wales, the only team still with a chance of achieving the Grand Slam.
15 Clement Poitrenaud, 14 Vincent Clerc, 13 Aurelien Rougerie, 12 Wesley Fofana, 11 Julien Malzieu, 10 Lionel Beauxis, 9 Julien Dupuy, 8 Julien Bonnaire, 7 Imanol Harinordoquy, 6 Thierry Dusautoir (captain), 5 Yohann Maestri, 4 Pascal Pape, 3 Nicolas Mas, 2 Dmitry Szarzewski, 1 Jean-Baptiste Poux
Substitutes: 16 William Servat, 17 Vincent Debaty, 18 Lionel Nallet, 19 Louis Picamoles, 20 Morgan Parra, 21 Francois Trinh-Duc, 22 Maxime Mermoz