Winger Cedric Heymans comes in for Julien Malzieu to make it an all-Toulouse back division, while in the pack another Toulouse player Romain Millo-Chluski takes over at lock from Sale's Sebastien Chabal.
Both props have been changed from the 21-30 to loss against Ireland in Dublin on Saturday with Nicolas Mas in for the injured Benoit Lecouls and Fabien Barcella taking over from Lionel Faure.
It remained to be seen whether Florian Fritz would be able to play at centre, however, as he is facing a suspension after being cited for a gouging incident during the Ireland game.
France:
15-Clement Poitrenaud, 14-Maxime Medard, 13-Yannick Jauzion, 12-Florian Fritz, 11-Cedric Heymans, 10-Lionel Beauxis, 9-Sebastien Tillous-Borde; 8-Imanol Harinordoquy, 7-Fulgence Ouedraogo, 6-Thierry Dusautoir, 5-Lionel Nallet (captain), 4-Romain Millo-Chluski, 3-Nicolas Mas, 2-Dimitri Szarzewski, 1-Fabien Barcella.
Replacements: 16-Benjamin Kayzer, 17-Renaud Boyoud, 18-Sebastien Chabal, 19-Louis Picamoles, 20-Morgan Parra, 21-Benoit Baby, 22-Julien Malzieu.