Dublin - Ireland have brought in Andrew Trimble and Jonathan Sexton for Saturday's Six Nations Grand Slam decider against England in Dublin.
The Irish RFU said in a statement on Wednesday that Trimble would come into the team on the left wing for his first start in this year's championship.
Sexton will take over at fly-half from Ronan O'Gara, who moves to the replacements bench, while Keith Earls moves from left wing to fullback in place of the dropped Luke Fitzgerald.
Eoin Reddan has been included in the starting lineup but the scrum-half remains a doubt after being concussed in the 19-13 defeat by Wales in Cardiff last Saturday. He will see a neurologist later this week to confirm if he is fit to play.
Scrum-half Tomas O'Leary, who had missed Ireland's last two games with a back problem, was ruled out on Tuesday due to an eye injury suffered when a strap snapped on a sled he was using for speed training.
Ireland have lost two matches in the tournament and would equal their worst Six Nations performance if they are beaten by England. In 2008 they lost three out of five games.
England travel to Dublin with the title almost certainly in their grasp but needing victory to complete their first Grand Slam in eight years.
15-Keith Earls, 14-Tommy Bowe, 13-Brian O'Driscoll (captain), 12-Gordon D'Arcy, 11-Andrew Trimble, 10-Jonathan Sexton, 9-Eoin Reddan; 8-Jamie Heaslip, 7-David Wallace, 6-Sean O'Brien, 5-Paul O'Connell, 4-Donncha O'Callaghan, 3-Mike Ross, 2-Rory Best, 1-Cian Healy.
Substitutes: 16-Sean Cronin, 17-Tom Court, 18-Leo Cullen, 19-Denis Leamy, 20-Peter Stringer, 21-Ronan O'Gara, 22-Paddy Wallace.