London - England centre Manu Tuilagi will miss Saturday's Six Nations opener against Scotland at Twickenham with an ankle injury, coach Stuart Lancaster announced Monday.
Meanwhile prop Alex Corbisiero has been ruled out of the entire championship with a knee problem.
Lancaster said England had "run out of time" to sort out Samoa-born Tuilagi's ankle injury but he was confident the Leicester centre would be training fully next Tuesday or Wednesday.
Tuilagi's loss is a blow to England ahead of this weekend's Calcutta Cup clash as the powerful midfielder played a key role in their record-breaking 38-21 win over world champions New Zealand at Twickenham last time out in December, scoring one and helping create two of the team's three tries.
Corbisiero damaged his knee during England's tour of South Africa last year but returned to action only for the injury to cause problems again after he played in England's stunning victory over the All Blacks.