Cape Town - Argentina flyhalf Nicolás Sánchez and wing Manuel Montero have been ruled out of Saturday's game against Australia.
The duo were initially named in Daniel Hourcade's side on Thursday but have both been withdrawn following Argentina's captain's run at Twickenham.
As a result Santiago González Iglesias moves to flyhalf, with Jerónimo de la Fuente coming in at inside centre to form a partnership with Matiás Orlando.
Montero meanwhile is replaced on the wing by Ramiro Moyano. Gabriel Ascarate and Lucas González Amorosino are both confirmed on the bench in the 22 and 23 jerseys.
Teams:
Argentina
15 Joaquín Tuculet, 14 Matías Moroni, 13 Matías Orlando, 12 Jerónimo De la Fuente, 11 Ramiro Moyano, 10 Santiago González Iglesias, 9 Martín Landajo, 8 Leonardo Senatore, 7 Javier Ortega Desio, 6 Pablo Matera, 5 Matías Alemanno, 4 Guido Petti, 3 Ramiro Herrera, 2 Agustín Creevy, 1 Lucas Noguera
Substitutes: 16 Julian Montoya, 17 Santiago García Botta, 18 Enrique Pieretto, 19 Marcos Kremer, 20 Juan Manuel Leguizamon, 21 Tomás Cubelli, 22 Gabriel Ascarate, 23 Lucas González Amorosino
Australia
15 Israel Folau, 14 Dane Haylett-Petty, 13 Samu Kerevi, 12 Bernard Foley, 11 Reece Hodge, 10 Quade Cooper, 9 Will Genia, 8 Lopeti Timani, 7 Michael Hooper, 6 Dean Mumm, 5 Adam Coleman, 4 Rory Arnold, 3 Sekope Kepu, 2 Stephen Moore (captain), 1 Scott Sio
Substitutes: 16 James Hanson, 17 Tom Robertson, 18 Allan Alaalatoa, 19 Kane Douglas, 20 Scott Fardy, 21 Leroy Houston, 22 Nick Phipps, 23 Tevita Kuridrani