Gold Coast - Nathan Sharpe will become the injury-hit Wallabies' fourth captain this year while Kurtley Beale has been dropped for their Rugby Championship clash with Argentina on Saturday.
Australia rallied from behind in Perth at the weekend to beat the Springboks 26-19 but it came at a cost with skipper Will Genia badly injuring his knee, which will keep him out for a prolonged period.
With first-choice captain James Horwill also sidelined, along with his successor David Pocock, Sharpe takes control for the showdown with the Pumas on the Gold Coast, the first Test to be played at the popular tourist destination.
"To have the privilege of leading Australia in the first ever Test to be played on the Gold Coast is an experience I will always treasure," said veteran Sharpe, 34, who has led the Wallabies twice before.
"But the memory is down the track. For now, it's important we keep our focus as a team, build on what we achieved last weekend in Perth, and add to that momentum.
"No one else in the squad has played Argentina before but I have and they will be tough, incredibly passionate and uncompromising.
"You only have to look at what they have achieved to date in their tournament matches to see what a threat they will be."
While winless in the championship to date, the Pumas have made both of their opponents uncomfortable, making most of the running in a 16-16 draw with South Africa at Mendoza last month.
They then gave the All Blacks a scare for much of last weekend's Test in Wellington, with the score locked at 6-5 at half-time. The Kiwis eventually won the game 21-5.
Argentina coach Santiago Phelan made two changes to his backline for Saturday's clash with halfback Nicolas Vergallo and fullback Martin Rodriguez dropped, replaced by Martin Landajo and Lucas Gonzalez Amorosino.
Vice-captain Patricio Albacete, a stand-out in the Argentine second-row, will earn his 50th cap, facing Sharpe who will make his 109th appearance.
Sharpe goes into the match with a new second row partner after a hamstring injury ruled out Perth man-of-the-match Sitaleki Timani, with Kane Douglas called on to take his maiden Test bow, the only change to the pack.
"He's a big man so he will help anchor the scrum on the tight head side in a similar way to how Sita has," said Wallabies coach Robbie Deans of Douglas.
Halfback Nick Phipps will step up for his fifth Test appearance to replace Genia.
A further change sees Berrick Barnes move from inside centre to fullback, to accommodate the return of regular inside centre Pat McCabe.
This means the out-of-form Beale, who started against South Africa, moves to the bench for the second time in three Tests after being dumped following his shocker in the opening game of the tournament against New Zealand in Sydney.
15 Berrick Barnes, 14 Dom Shipperley, 13 Adam Ashley-Cooper, 12 Pat McCabe, 11 Digby Ioane, 10 Quade Cooper, 9 Nick Phipps, 8 Radike Samo, 7 Michael Hooper, 6 Dave Dennis, 5 Nathan Sharpe (captain), 4 Kane Douglas, 3 Ben Alexander, 2 Tatafu Polota Nau, 1 Benn Robinson
Substitutes: 16 Stephen Moore/Saia Fainga'a, 17 James Slipper, 18 Scott Higginbotham, 19 Liam Gill, 20 Brett Sheehan, 21 Anthony Fainga'a, 22 Kurtley Beale
15 Lucas Gonzalez Amorosino, 14 Gonzalo Camacho, 13 Marcelo Bosch, 12 Santiago Fernandez, 11 Horacio Agulla, 10 Juan Martin Hernandez, 9 Martin Landajo, 8 Juan Martin Fernandez Lobbe (captain), 7 Juan Manuel Leguizamon, 6 Julio Farias Cabello, 5 Patricio Albacete, 4 Manuel Carizza, 3 Juan Figallo, 2 Eusebio Guinazu, 1 Rodrigo Roncero
Substitutes: 16 Agustin Creevy, 17 Juan Pablo Orlandi, 18 Leonardo Senatore, 19 Toms Leonardi, 20 Nicolas Vergallo, 21 Martin Rodriguez, 22 Juan Imhoff