Cape Town - Two Springboks will make their debuts against the Wallabies at Loftus Versfeld on Saturday, while a third could make his mark off the bench.
In naming his 23-man squad for the clash in Pretoria, coach Allister Coetzee handed Stormers prop Vincent Koch and Bulls scrumhalf Rudy Paige the opportunity to make their maiden starts against Australia.
In addition, Lions front-rower Julian Redelinghuys will also get a taste of life against the Wallabies should he be used as a substitute.
The Boks have a perfect 5-from-5 record in previous Rugby Championship matches against Australia at Loftus, with an average winning margin of 18 points (36-18).
Saturday's clash will be the 83rd between South Africa and Australia since they first clashed on July 8, 1933 at Newlands in Cape Town (Boks won 17-3).
Of the previous 82 encounters, the Springboks have won 45, lost 36 with one draw.
The Springboks' biggest victory over Australia came during the 2008 Tri-Nations when Peter de Villiers' men triumphed 53-8 in Johannesburg.
Sadly, in one of SA rugby's darkest days, their biggest defeat to the Wallabies came during the 2006 Tri-Nations in Brisbane when Jake White's side crashed to a 49-0 loss.
Teams:
Springboks
15 Pat Lambie, 14 Bryan Habana, 13 Jesse Kriel, 12 Juan de Jongh, 11 Francois Hougaard, 10 Morne Steyn, 9 Rudy Paige, 8 Warren Whiteley, 7 Oupa Mohoje, 6 Francois Louw, 5 Pieter-Steph du Toit, 4 Eben Etzebeth, 3 Vincent Koch, 2 Adriaan Strauss (captain), 1 Tendai Mtawarira
Substitutes: 16 Bongi Mbonambi, 17 Steven Kitshoff, 18 Julian Redelinghuys, 19 Lood de Jager, 20 Willem Alberts, 21 Jaco Kriel, 22 Lionel Mapoe, 23 Willie le Roux
Wallabies
15 Israel Folau, 14 Dane
Haylett-Petty, 13 Samu Kerevi, 12 Bernard Foley, 11 Reece Hodge, 10 Quade
Cooper, 9 Will Genia, 8 Sean McMahon, 7 Michael Hooper, 6 Dean Mumm, 5 Rob
Simmons, 4 Adam Coleman, 3 Sekope Kepu, 2 Stephen Moore (captain), 1 Scott Sio
Substitutes (from): 16 James Hanson, 17 James Slipper, 18 Tom Robertson, 19
Kane Douglas, 20 Scott Fardy, 21 Lopeti Timani, 22 Nick Phipps, 23 Tevita
Kuridrani, 24 Sefa Naivalu