Rome - Player release has forced Argentina into five changes for their closing tour match against Italy on Saturday from the team beaten 40-6 by Wales last weekend.
The Pumas will be without first-choice centres Marcelo Bosch and Santiago Fernandez and lock Patricio Albacete due to an agreement between their European clubs and Argentina.
The players have been with the Pumas since August taking part in the southern hemisphere's Rugby Championship, missing the early part of the European season with their clubs.
Coach Daniel Hourcade has moved left wing Horacio Agulla into Bosch's outside centre position in the team he named on Thursday, the Argentine union UAR said in a statement.
Hourcade has brought Lucas Gonzalez Amorosino back into the side on the right wing while Gabriel Azcarate takes the inside centre berth left vacant by Fernandez to make up an untested midfield partnership with Agulla.
Juan Imhoff, injured in Argentina's 31-12 defeat by England two weeks ago, returns to the left wing with Santiago Cordero, who made his first Pumas start against the Welsh, stepping back down to the bench.
Bosch has returned to Saracens and Fernandez to Bayonne in France, while in the forwards, lock Mariano Galarza comes in for Albacate, who has gone back to Toulouse.
In the back row, Benjamin Macome comes in at number eight with Pablo Matera dropping down to the bench and captain Juan Manuel Leguizamon moving to blindside flanker.
McLean, 14 Giovambattista Venditti, 13 Michele Campagnaro, 12 Gonzalo
Canale, 11 Tommaso Iannone, 10 Tommaso Allan, 9 Edoardo Gori, 8 Sergio
Parisse (captain), 7 Robert Barbieri, 6 Alessandro Zanni, 5 Valerio
Bernabo, 4 Quintin Geldenhuys, 3 Martin Castrogiovanni, 2 Leonardo
Ghiraldini, 1 Michele Rizzo
Substitutes: 16 Davide Giazzon, 17
Matias Aguero, 18 Lorenzo Cittadini, 19 Marco Bortolami, 20 Joshua
Furno, 21 Tobias Botes, 22 Luciano Orquera, 23 Tommaso Benvenuti.
15 Joaquin Tuculet, 14-Lucas Gonzalez Amorosino, 13-Horacio
Agulla, 12 Gabriel Azcarate, 11 Juan Imhoff, 10 Nicolas Sanchez, 9
Martin Landajo; 8 Benjamin Macome, 7 Julio Farias Cabello, 6 Juan Manuel
Leguizamon (captain), 5 Mariano Galarza, 4 Manuel Carizza, 3
Maximiliano Bustos, 2 Eusebio Guinazu, 1 Marcos Ayerza
16 Santiago Iglesias, 17 Nahuel Lobo, 18 Matias Diaz, 19 Tomas
Lavanini, 20 Pablo Matera, 21 Tomas Cubelli, 22 Javier Rojas, 23