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Five players made their England debuts in the 32-3 win over the Pumas in Salta with winger Christian Wade and flanker Matt Kvesic starting.
Billy Vunipola, Henry Thomas and Kyle Eastmond also won their first caps on the bench as Lancaster's men went halfway to becoming the first English side to win 2-0 in Argentina.
Number 8 Ben Morgan also played his first international since the opening game of the Six Nations after an ankle injury.
Lancaster's side went off the boil in the second half, after leading 25-3 at half-time, and the head coach has warned there could be changes despite the convincing first Test victory.
"We have got one or two changes we will make because we want to look at some players but we have only got a small squad here so there won't be too many," he told reporters after the match in Salta.
"I am pleased we didn't concede a try but we can't concede 15 penalties next week so we need to improve our discipline.
"In attack our intent and the speed we played were good and some of the tries were excellent - we looked cohesive and we looked organised. Two nil is a huge incentive. It has not been achieved but we have got plenty to work on.
"I said to the players in the team talk that I wanted England to develop the type of game that can win consistently at the highest level and for parts of the game we took some steps in achieving that.
"But we have got to do it for 80 minutes and do it consistently and that is the challenge for next week. We need to be more accurate.
"The Pumas deserve a lot of credit for the way they came back in the second half. They made it very difficult and we need to improve going into next week."
Kvesic got his chance after Chris Robshaw was rested for this trip whilst Wade made the most of Chris Ashton's absence.
And both look likely to escape being dropped next week after being prominent in the four-try win.
"I was really pleased with Matt Kvesic - his involvement in the game was high and in and around the breakdown," said Lancaster.
"He was strong considering it was his first time at this level and Christian (Wade) did what he does in the Premiership - he sets our attack alight. It was a big step and he has been great for us.
"Ben Morgan has an uncanny ability to be where the ball is kicked and he has a good ability to pass and offload and he is a pretty effective ball carrier. But by the same token it was good to get Billy Vunipola on."
