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Cardiff - Cardiff Blues centre Cory Allen is in line to make his Test debut this weekend after being named on Thursday in the starting side to play Argentina.
At the other end of the spectrum, prop Gethin Jenkins will become only the fourth player to win 100 Wales caps after Stephen Jones, Gareth Thomas and Martyn Williams when he takes the field at Cardiff's Millennium Stadium on Saturday.
Wales coach Warren Gatland made four changes to the side beaten 24-15 by South Africa in Cardiff last weekend.
Allen replaced the injured Jonathan Davies in midfield while fly-half Dan Biggar was selected to start in place of Rhys Priestland.
Up front, Rhodri Jones took over from injured veteran prop Adam Jones (calf) while Dan Lydiate was ruled out with an ankle problem.
Lydiate's injury led to a back-row reshuffle with Justin Tipuric starting at openside flanker and captain Sam Warburton moving to the blindside.
Six Nations champions Wales will be out for revenge following last year's 26-12 defeat by the Pumas in Cardiff.
Argentina will face Wales at the Millennium Stadium on Saturday (1430 GMT) with four changes from the team beaten by England in their opening tour match.
Coach Daniel Hourcade named a team on Thursday with three changes in the backs and one in the forwards following last Saturday's 31-12 defeat at Twickenham, the Argentine union UAR said in a statement.
Wing Santiago Cordero, who made his Pumas debut off the bench against England, makes his first start in place of the injured Juan Imhoff.
Scrumhalf Martin Landajo replaces Tomas Cubelli and Joaquin Tuculet plays at fullback in place of Lucas Gonzalez Amorosino.
Manuel Carizza comes in at lock for Mariano Galarza, who has returned to Worcester in an agreement between Argentina and the English club for the release this time of back row forward Leonardo Senatore, who starts on the bench.
Argentina will be looking to repeat their victory over Wales during their last European tour a year ago, when the Pumas won 26-12.
Teams:
Wales
15-Leigh Halfpenny; 14-George North, 13-Cory Allen, 12-Scott Williams, 11-Liam Williams; 10-Dan Biggar, 9-Mike Phillips; 8-Toby Faletau, 7-Justin Tipuric, 6-Sam Warburton (capt); 5-Alun Wyn Jones, 4-Bradley Davies; 3-Rhodri Jones, 2-Richard Hibbard, 1-Gethin Jenkins
Replacements: 16-Ken Owens, 17-Paul James, 18-Samson Lee, 19-Luke Charteris, 20-Ryan Jones, 21-Lloyd Williams, 22-James Hook, 23-Ashley Beck
Argentina
15-Joaquin Tuculet, 14-Horacio Agulla, 13-Marcelo Bosch, 12-Santiago Fernandez, 11-Santiago Cordero, 10-Nicolas Sanchez, 9-Martin Landajo; 8-Juan Manuel Leguizamon (captain), 7- Julio Farias Cabello, 6-Pablo Matera, 5-Patricio Albacete, 4-Manuel Carizza, 3-Maximiliano Bustos, 2-Eusebio Guinazu, 1-Marcos Ayerza
Replacements: 16-Santiago Iglesias, 17-Nahuel Lobo, 18-Matias Diaz, 19-Tomas Lavanini, 20-Leonardo Senatore, 21-Tomas Cubelli, 22-Gabriel Azcarate, 23-Lucas Gonzalez Amorosino
