Durban - Alberto Di Bernardo has become the latest in a long line of flyhalves entrusted with Italy's No 10 jersey after the 33-year-old was handed his debut for the Test against South Africa in Durban on Saturday.
Kick-off is at 17:15.
The Treviso player excelled in the Celtic League last term and replaces fellow Argentina-born Luciano Orquera, who drops to the bench having been the main flyhalf during Italy's strong Six Nations campaign in February and March when they beat France and Ireland.
Edoardo Gori continues at scrumhalf as he looks to make the spot his own in a mini-series also involving Samoa and Scotland.
Lock and former captain Marco Bortolami returns to the line-up after a year out following a shoulder injury.
15 Willie le Roux, 14 Bryan Habana, 13 JJ
Engelbrecht, 12 Jean de Villiers (captain), 11 Bjorn Basson, 10 Morné Steyn, 9 Jano
Vermaak, 8 Pierre Spies, 7 Willem Alberts, 6 Francois Louw, 5 Juandré Kruger, 4
Eben Etzebeth, 3 Jannie du Plessis, 2 Adriaan Strauss, 1 Beast Mtawarira
16 Chiliboy Ralepelle, 17 Trevor Nyakane, 18 Coenie Oosthuizen, 19 Flip van der
Merwe, 20 Arno Botha, 21 Ruan Pienaar, 22 Pat Lambie, 23 Jan Serfontein
15 Andrea Masi, 14 Giovanbattista Venditti, 13 Luca Morisi,
12 Alberto Sgarbi, 11 Luke Mclean, 10 Alberto Di Bernardo, 9 Edoardo
Gori, 8 Sergio Parisse (captain), 7 Robert Barbieri, 6 Alessandro Zanni, 5 Marco
Bortolami, 4 Antonio Pavanello, 3 Lorenzo Cittadini, 2 Leonardo
Ghiraldini, 1 Alberto De Marchi
Substitutes: 16 Davide
Giazzon, 17 Matias Aguero, 18 Martin Castrogiovanni, 19 Valerio Bernabo,
20 Joshua Furno, 21 Tobias Botes, 22 Luciano Orquera, 23 Tommaso