Aberdeen - Glasgow scrumhalf Henry Pyrgos is set to make his first Scotland start after being named in the XV to play Tonga in Aberdeen on Saturday.
Pyrgos was one of five changes announced by coach Andy Robinson on Wednesday in response to last weekend's 21-10 defeat by South Africa at Murrayfield where the Warriors No 9 came off the bench to replace Mike Blair.
Blair, lock Jim Hamilton and hooker have been dropped from the matchday 23 completely as Scotland look to end their autumn series with victory after defeats by world champions New Zealand (51-22) and the Springboks.
Scott Lawson starts in place of former captain Ford, with Alastair Kellock lining up in the second row alongside Richie Gray, who suffered concussion against South Africa and will continue to be monitored.
Alasdair Strokosch, a late withdrawal from the starting XV to play the Springboks due to a calf injury, returns in place of John Barclay, while in the backs Max Evans starts at outside centre, with Nick De Luca dropping down to the replacements' bench.
15 Stuart Hogg, 14 Sean Lamont, 13 Max Evans, 12 Matt Scott, 11 Tim Visser, 10 Greig Laidlaw, 9 Henry Pyrgos, 8 David Denton, 7 Kelly Brown (captain), 6 Alasdair Strokosch, 5 Alastair Kellock, 4 Richie Gray, 3 Euan Murray, 2 Scott Lawson, 1 Ryan Grant
Substitutes: 16 Dougie Hall, 17 Kyle Traynor, 18 Geoff Cross, 19 Grant Gilchrist, 20 John Barclay, 21 Rory Lawson, 22 Tom Heathcote, 23 Nick de Luca