Port Elizabeth - England loosehead prop Alex Corbisiero has been ruled out of the third Test against South Africa after suffering a recurrence of a knee injury, team management announced on Friday.
The 23-year-old Corbisiero made an immediate impact when he came off the bench during England's 36-27 defeat in the second Test against the Springboks and was rewarded with a place in the starting side for the final Test of the series on Saturday.
Corbisiero's place will now be taken by Joe Marler, who will move up from the bench to make his third appearance, with Paul Doran Jones drafted in as one of the replacements.
"Alex trained well early in the week having played well at the weekend but the knee reacted over the last 24 hours," England head coach Stuart Lancaster said in a statement.
"It is a shame for Alex as he was desperate to take part but it's the right thing to put in Joe and we are sure he can build on his performances in the first two Tests," added Lancaster.
15 Gio Aplon, 14 JP Pietersen, 13 Jean de Villiers (captain), 12 Wynand Olivier, 11 Bryan Habana, 10 Morne Steyn, 9 Francois Hougaard, 8 Pierre Spies, 7 Jacques Potgieter, 6 Marcell Coetzee, 5 Juandre Kruger, 4 Eben Etzebeth, 3 Jannie du Plessis, 2 Bismarck du Plessis, 1 Tendai Mtwarira
Substitutes: 16 Adriaan Strauss, 17 Werner Kruger, 18 Flip van der Merwe, 19 Ryan Kankowski, 20 Ruan Pienaar, 21 Elton Jantjies, 22 Bjorn Basson
15 Alex Goode, 14 Chris Ashton, 13 Jonathan Joseph, 12 Manu Tuilagi, 11 Ben Foden, 10 Toby Flood, 9 Danny Care, 8 Thomas Waldrom, 7 James Haskell, 6 Tom Johnson, 5 Geoff Parling, 4 Tom Palmer, 3 Dan Cole, 2 Dylan Hartley (captain), 1 Joe Marler
Substitutes: 16 Lee Mears, 17 Paul Doran Jones, 18 Mouritz Botha, 19 Phil Dowson, 20 Lee Dickson, 21 Owen Farrell, 22 Brad Barritt