Flank Luvuyiso Lusaseni has fallen ill, and he is replaced by Dries van Schalkwyk in the run-on team.
Roan van Heerden takes Van Schalkwyk's place on the bench.
The Leopards had previously made two changes to the team that lost 42-23 against the Lions in Potchefstroom last week.
Prop John Roy Jenkinsons, who picked up an injury, was replaced by Berend Botha in the starting XV, and Wynand Willis was added to the bench.
Teams
Leopards: 15 George Tossel, 14 Hoffman Maritz, 13 Charl Weideman, 12 Joubert Engelbrecht (captain), 11 Jovan Bowles, 10 Wesley Dunlop, 9 Johann Laker, 8 Robert Kruger, 7 Luvuyiso Lusaseni, 6 Philip de Wet, 5 Bradley Mockford, 4 Brendon Snyman, 3 Berend Botha, 2 Gavin Williamson, 1 Jean Rossouw
Substitutes: 16 Marius Fourie, 17 Dewald Coetzee, 18 Juan Pretorius, 19 Dries van Schalkwyk, 20 Liam Slatem, 21 Wynand Willis, 22 Clayton Durand
Pumas:
TBA