The Lions have won two of their first three encounters in the early stages of the domestic campaign, and while Griquas have yet to win a match, they have led all of their games until half-time, with only their inability to finish breaking their stride.
"They are a quality side that can beat anyone on any day," said interim Lions coach Johan Ackermann.
"Yes, they have lost three in a row, but they were sitting pretty till half-time in all their encounters and just couldn't close out.
"They are always a dangerous outfit, no matter what."
Ackermann backed regular flank and former Lions skipper Joshua Strauss, who packs down at lock for the clash.
"Josh played some good rugby when he was moved to lock against Western Province," he said.
"We are looking for more of the same from him against Griquas.
"And of course there is his ability with the ball in hand that will also play a pivotal role."
Griquas coach Pote Human said his players were in need of a victory to relieve some of the pressure.
"We know that it is crunch time. There is already talk of a promotion and relegation match, but we choose to focus on the job at hand," Human said.
"The last couple of games we fell into a slump after half-time.
"We can ill-afford that against the Lions. We need to be in the driver's seat from the get go and stay there for the full 80 minutes."
Despite their recent failures, Human believed Griquas had been solid in set pieces.
"We are happy with where we are with regards to our scrums and lineouts," he said.
"They do give us solid platforms to attack from, but the main thing is we need to play the full 80 minutes.
"If not, it is going to be a long and difficult evening."
Teams:
Golden Lions: 15 Andries Coetzee, 14 JR Esterhuizen, 13 Lionel Mapoe, 12 Butch James, 11 Anthony Volmink, 10 Elton Jantjies, 9 Ross Cronje, 8 Warren Whiteley, 7 Willie Britz, 6 Jaco Kriel, 5 Franco van der Merwe, 4 Joshua Strauss, 3 CJ Van der Linde, 2 Bandise Maku, 1 JC Janse van Rensburg (captain).
Substitutes: 16 Martin Bezuidenhout, 17 Ruan Dreyer, 18 Michael Rhodes, 19 Cobus Grobbelaar, 20 Michael Bondesio, 21 Alwyn Hollenbach, 22 Deon Helberg.
Griqiuas: 15 Willie le Roux 14 Jannie Boshoff 13 Jean Stemmet 12 Walter Venter 11 Rocco Jansen 10 Francois Brummer 9 Marnus Hugo 8 Leon Karemaker 7 Wesley Wilkins 6 Marnus Schoeman 5 Martin Muller 4 Ligtoring Landman 3 Lourens Adriaanse 2 Ryno Barnes (captain) 1 Steph Roberts
Substitutes: 16 Matthew Dobson 7 Ivann Espag 18 Frikkie Spies 19 Justin Downey 20 Jacques Coetzee 21 Marnitz Boshoff 22 Matthew Rosslee