Louw, 29, last played for the Springboks in their Rugby Championship Test against the All Blacks in Wellington on September 13.
He underwent neck surgery 10 weeks ago and will make his return for his English club, Bath, in a European Champions Cup game against Montpellier on Friday.
“Francois has been training for some time and it’s been a case of
just making sure that everyone is happy medically,” Bath coach Toby Booth told the Bath Chronicle.
“We’ve no issues with throwing him straight in. We’re not worried. He’s been training well, and he was thrown in for the final of the European Challenge Cup last season and did very well.”
Louw's return will no doubt please Springbok coach Heyneke Meyer.
The fetcher flank's absence on the Boks' recent year-end tour to Europe was evident to see as the South Africans struggled on the ground.
The Boks beat England and Italy on tour, but lost two of their four matches - to Ireland in Dublin and Wales in Cardiff.