"When I see two women face to face in a boxing ring, it makes me feel nausea. I am not really a fan of female boxing," he said on Sunday.
"This sport is appropriate for men, but not for women," the Ukrainian told Die Welt newspaper.
"I hope women will not take it badly; perhaps I am old or conservative, but I consider there are sports much more beautiful for women than boxing," he added.
The International Olympic Committee announced last August that women's boxing would be included on the list of events for London in 2012, but Klitschko said he would not be watching.
Klitschko, whose brother Wladimir retained his IBF and WBO titles by knocking out US challenger Eddie Chambers on Saturday, will defend his WBC crown against Poland's Albert Sosnowski in Gelsenkirchen on May 29.