Cape Town - South Africa's Dina Lebo Phalula and Christine Kalmer finished in 63rd and 96th position, respectively, in the women's marathon at the Rio Games on Sunday.
Flanked by Viktoriia Poliudina of Kyrgyzstan and Andrea Mayr of Austria, Phalula clocked a time of 2:41:46 - and Kalmer 2:48:24.
Kenya's Jemima Sumgong clinched a gold medal in a time of 2:24;04, while Eunice Kirwas of Bahrain took silver - and Tirunesh Dibaba of Ethiopia bronze.
Ethiopian Mestawet Tufa, who came second in the London Marathon earlier this year, was among the race favourites, but withdrew about an hour into proceedings.
South African Irvette van Zyl had withdrawn 24 hours prior. Van Zyl sustained a stress fracture of the foot earlier this week.
"She was treated by the physiotherapists on Thursday and Friday. She complained of pain on her foot and was taken, by the chief medical officer to the polyclinic for an MRI scan," read a statement from the South African Sports Confederation and Olympic Committee.
"She has had to be placed in a moon boot and is now using crutches. She is effectively ruled out of participation in her event."