Rome - Roman Kreuziger, Joaquim Rodriguez and Frank Schleck spearhead a foreign legion hoping to end Italian hopes of scoring a home win in the Giro d'Italia, which begins on Saturday in Herning, Denmark.
In 66 of the 94 previous editions Italians have claimed the race's coveted pink jersey.
Italians Michele Scarponi, Ivan Basso and Damiano Cunego have all been crowned Giro champions and will be looking to stay in contention throughout a 21-stage epic which, although including three time trials, should have the climbing specialists licking their lips.
The 95th edition has been billed as wide open, meaning they are likely to be pushed all the way.
Kreuziger, 25, has decided to skip the Tour de France this year to concentrate on trying to win one of the other two Grand Tours.
An all-rounder with good time-trialling and climbing abilities, he finished fifth last year having impressed with two consecutive top 10 places at the Tour de France in the two previous years.
"I've stepped up every year since 2008. I haven't won a grand tour but I'm confident that I'm progressing," said Kreuziger, who finished sixth overall at the Tour of Romandie on Sunday.
"My season is going well. I had a good Tirreno-Adriatico, Giro del Trentino and Tour de Romandie. We'll see if it's my year."
Rodriguez has never won a Grand Tour but the former winner of the Tour of Spain's King of the Mountains prize finished seventh at the 2010 Tour de France and was fourth at the Giro in 2011.
"In Spain they say I'm the biggest favourite to win the Giro for several years," admitted the Spaniard.
"I don't think there's one big favourite in the race. There are a lot of riders who can win the Giro, including some who could cause a surprise."
Luxemburger Schleck could fall into that category. He was shocked to be called up at the last minute by RadioShack after Danish team-mate Jakob Fuglsang got injured.
"I was at the playground with my daughter when I got the call and was asked to ride the Giro d'Italia," said Schleck, who finished third in last year's Tour.
"It was a shock but then I looked at the race route and realised it's a good opportunity for me."
Last year's race was won by Spain's Alberto Contador, but after his results over the last two years were annulled due to doping offences Lampre all-rounder Scarponi will start as the official defending champion.
He was presented with the pink jersey on Thursday, but said: "I want to taste the feeling of winning the pink jersey on the roads, that's going to be my true motivation in the 2012 Giro.
"There are a lot of favourites this year, who all have an equal chance of victory or to climb on the podium."
Basso, the outstanding competitor in the field when he won in 2006 and 2010, will spearhead the Liquigas team's bid.
Despite not being the rider he once was, Basso is hoping to show that his mediocre start to the season was a blip.
"Two crashes cost me two weeks of important racing early in the season but I've done a lot more work in the last 40 days," he said.
"I'm 34 and I've got to trust my experience. We'll see stage by stage but I'm confident I can fight for success with the best riders in the race."
Cunego, the 2004 champion, is likely to work for his team leader Scarponi but the 'Little Prince' could come into his own in the climb-heavy third week.
Four of the six stages in the last week will be spent in the thin air of the high mountains, giving the likes of Italian Domenico Pozzovivo and Venezuelan Jose Rujano outside chances of a top finish.
French climbing specialist John Gadret, who finished a surprise but deserved third last year, is hoping to do even better.
"I wasn't a favourite last year but I proved what I could do," he said.
"I'll try and do the same, if not even better. The last week of the route is very difficult, all the stages are tough.
"But it's the riders who make the race."
A list of the 21 stages of the 2012 Giro d'Italia, starting in Herning, Denmark on Saturday and finishing on May 27 in Milan:
Stage 1 - May 5: Herning (Denmark) - Herning (8.7km, time trial)
Stage 2 - May 6: Herning - Herning (206km)
Stage 3 - May 7: Horsens (Denmark) - Horsens (190km)
Rest Day - May 8
Stage 4 - May 9: Verona - Verona (33.2km team time trial)
Stage 5 - May 10: Modena - Fano (209km)
Stage 6 - May 11: Urbino - Porto Sant'Elpidio (210km)
Stage 7 - May 12: Recanati - Rocca di Cambio (205km)
Stage 8 - May 13: Sulmona - Lago Laceno (229km)
Stage 9 - May 14: San Giorgio del Sannio - Frosinone (166km)
Stage 10 - May 15: Civitavecchia - Assisi (186km)
Stage 11 - May 16: Assisi - Montecatini Terme (255km)
Stage 12 - May 17: Seravezza - Sestri Levante (155km)
Stage 13 - May 18: Savona - Cervere (121km)
Stage 14 - May 19: Cherasco - Cervinia (206km)
Stage 15 - May 20: Busto Arsizio - Lecco/Piani dei Resinelli (169km)
Rest Day - May 21
Stage 16 - May 22: Limone sul Garda - Falzes (173km)
Stage 17 - May 23: Falzes - Cortina d'Ampezzo (186km)
Stage 18 - May 24: San Vito di Cadore - Vedelago (149km)
Stage 19 - May 25: Treviso - Alpe di Pampeago (198km)
Stage 20 - May 26: Caldes/Val di Sole - Passo dello Stelvio (219km)
Stage 21 - May 27: Milan - Milan (30km time trial)