Alcaudete - Italy's Alessandro de Marchi sprinted home alone to win the seventh stage of the Tour of Spain on Friday as Spaniard Alejandro Valverde held the race lead.Cannondale's de Marchi, 28, shook off his three breakaway rivals with 15km to go, holding off all their attempts to catch him after the mountainous 169km ride from Alhendin to Alcaudete.
Canada's Ryder Hesjedal of Garmin finished second, despite crashing near the finish, ahead of France's Hubert Dupont of the Ag2r-La Mondiale team.
De Marchi was elated having tried several times in vain to win a stage during last month's Tour de France.
"I've been waiting for this moment," the Italian told Spanish television station TVE.
"Today I managed to find the opening and I had a bit of luck. I came to this Vuelta without pressure, taking it day by day."
On what was supposed to be a transitional stage ahead of Sunday's first big mountain challenge, there were some worrying moments, most notably when last year's Tour winner Chris Froome went down early on.
Although the British Team Sky leader seemed to hurt his leg, the peloton sat up for him and he easily rejoined the pack.
And he even took back a couple of seconds on Valverde in the sprint finish as he came home seventh.
He remains fourth although now just 20sec behind the Spanish Movistar rider.
Colombian Giro d'Italia champion Nairo Quintana, Valverde's team-mate and overall favourite, is second at 15sec with two-time former Vuelta winner Alberto Contador third at 18sec.
Young French climber Warren Barguil, thought by many as a potential future Tour champion, was another to hit the deck.
However, as the 22-year-old Giant-Shimano leader's crash came in the final few kilometres, he was not penalised by any time loss and stays ninth at just over a minute.
Saturday's 207km flat stage from Baeza to Albacete is one for the sprinters.
Results on Friday from the seventh stage of the 69th Spanish Vuelta, a 169km ride from Alhendin to Alcaudete (rider, country, team, time):
1. Alessandro de Marchi, Italy, Cannondale, 4 hours, 1 minute, 52 seconds.
2. Ryder Hesjedal, Canada, Garmin Sharp, 1 minute, 34 seconds behind.
3. Hubert Dupont, France, AG2R La Mondiale, 1:35.
4. Johann Tschopp, Switzerland, IAM, same time.
5. Philippe Gilbert, Belgium, BMC, 2:17.
6. Daniel Martin, Ireland, Garmin Sharp, same time.
7. Chris Froome, Britain, Sky, 2:18.
8. Gianluca Brambilla, Italy, Omega Pharma-Quickstep, 2:20.
9. Alejandro Valverde, Spain, Movistar, same time.
10. Alberto Contador, Spain, Tinkoff-Saxo, same time.
Overall Standings (After 7 of 21 stages)
1. Alejandro Valverde, Spain, Movistar, 26 hours, 52 minutes, 20 seconds.
2. Nairo Quintana, Colombia, Movistar, 15 seconds behind.
3. Alberto Contador, Spain, Tinkoff-Saxo, :18.
4. Chris Froome, Britain, Sky, :20.
5. Esteban Chaves Rubio, Colombia, Orica GreenEdge, :41.
6. Joaquin Rodriguez, Spain, Katusha, :45.
7. Robert Gesink, Netherlands, Belkin, :55.
8. Fabio Aru, Italy, Astana, :58.
9. Warren Barguil, France, 1:02.
10. Wilco Kelderman, Netherlands, Belkin, 1:06.