Bafana will face their toughest test yet under coach Gordon Igesund when they welcome Spain to the FNB Stadium.
Kick-off is at 21:00.
The world and double European champions represent the apex of international football and will be returning to the scene of their greatest triumph, having claimed the 2010 Soccer World Cup at the iconic Soccer City venue.
Spain will however be without several key players who were central to their 2010 triumph, most notably Xavi, Fernando Torres and Xabi Alonso, but in the likes of Andres Iniesta, Juan Mata and Iker Casillas they still boast some of the finest players in the business.
Here are Sport24 readers score predictions for the game.
"South Africa 1-5 Spain - They are going to hammer us with that Kind of squad I dont see South Africa doing the country proud but an Embarrassment"- Teboho Mokone
"Lets support our boys, instead of been al negative, no one from spain will adopt you, bafana all the way, #proudly_south_african" - Aubrey Jaybee Seven Ramasepela
"draw 2'2" - Litha Ngalonkulu Usher
"Spain 6-0 Iguson" - Sabelo Mhlongo Khulamini
"Sa 2 spain 1" - SJ Lubisi
"Spain 6- 0 SA" - Wicus Caroll-Ann Mienie
"spain 10-0 sa" - Willem Nieman
"This wl b worst lose 4 bafana.l tel u" - Allas Alaska Nyoni
"Spain 4 - 0" - Andre Rietoff
"4 to Spain 0 to Bafana" - Marck Williams
"8-0" - Siya Lokwe
"SA~8 cornerkicks ~spain 5goals" - Marico Links
"Spain 3-1" - Charles Mikael Ekström
"3-1 for spain" - Martin Smit
"0-0" - Maganyele Stan
"2 All draw." - Sikholiwe Mavusie Hanqa
"Spain 7 bantana bantaka 0.........." - Eugene Maasdorp
"It wil b 1 all draw" - Tafadzwa Highlanders Fc Choruwah
"Spain 8- South Africa 1" - Gary William Reilly
"With or without fixing?" - Richard Russmann
"4-0" - Dyllan Roberts
"SA 0-4 ESP" - Hugoh Boss
"2-1 bafana." - Ryno Peters
"5 spain 2 bafana" - Levy Legodi
"S.A 2-0 Spain" - Sibusiso Chopper Mnisi
"5~0 spain" - Robert Wickham
"3-1" - SirThabo Mogadima
"It will be a draw" - Mabhiza Mshengu
"Spain 4-0 Bafana" - Barnard Leonard
"1-1" - Johann Friedrich Biermann
"spain 7 bafana 0" - Patrick Tiras
"Spain to win 3-0" - Charlie Nel
"0-3....Spain all the way" - Joel Napo
"Is our Hero playing Khune, y worrie hehehehe!!!! lmklaaaaaa" - Lloyd Peter Bosman
"Spain 3 - SA 0" - Lesedi Lesley
"0-0!" - Fanozi Shazi
"Bafana 1 - 0 spain" - Tshepo Buccuneer Mohapi
"Spain 2-1 Bafana" - Mxoliso Vincent Tshoba
"10-0 Spain National Football Team" - Theann Jandre Botha
"Draw 2:2" - Thathana Thikundwi Vincent
Spain to punish Bafana? (Gallo Images)