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Three-times winner Woods pulled out of the tournament last week because of injuries to his left knee and Achilles tendon and Scott has recruited the former world number one's caddie, Steve Williams, for the year's second major.
"It's been great," Scott told Reuters on a sun-splashed Wednesday at Congressional while preparing for Thursday's opening round.
"We've known each other for a long time and he's obviously one of the best caddies out here. I'm sure everything's going to go well."
New Zealander Williams, who has previously caddied for players such as Australian Greg Norman and American Raymond Floyd, was on Woods's bag for 13 of his 14 major victories.
"It's nice to have an experienced man there next to me like I've always had," said Scott, who split with veteran caddie Tony Navarro after the PGA Tour's Players Championship last month.
"Hopefully I can get Steve in the position that he's used to in these things (majors) and then his real talent will come out."
A seven-times winner on the PGA Tour, Scott has mainly struggled at the US Open where he has missed five cuts in nine career starts.
He recorded his best finish with a tie for 21st at Winged Foot in 2006 but believes he is in good shape for Congressional this week.
"My preparations have gone well so I'm looking forward to tomorrow morning," said the 30-year-old Australian. "I've got a good handle to the course now so I am just excited to get this week under way."
Scott has produced a varied bag of form this season, mixing three missed cuts with two top-10s in nine PGA Tour starts.
However, the world number 21 will take a great deal of confidence from his tie for second at the Masters in April, his best finish in the opening major of the year.
"Augusta was obviously a great week," Scott recalled with a smile. "It was really nice to be in the mix late on Sunday afternoon, and it was nice to play well in that situation.
"I felt I did everything I could and I was simply outplayed at the end. But I know that I can take positives out of that in how I performed late on Sunday. I was very happy with that."
Scott is scheduled to tee off with Swede Robert Karlsson and long-hitting American Bubba Watson in Thursday's opening round at Congressional.
