The Titans outfit is littered with national players, while the Lions will have only regular captain Alviro Petersen returning to the side for Sunday's season finale.
Lions coach Dave Nosworthy believed the visitors would face a selection headache, with a number of international players available for the Titans after South Africa returned from a seven-week tour of New Zealand on Wednesday.
"Alviro is available to us as far as we're aware... and he will come straight back into the team as captain," Nosworthy said.
"Thami [Tsolekile] was obviously our stand-in captain [while Petersen was on Test duty].
"There are more issues when you change four or five places. That's always a whole dynamic that changes.
"But throughout this season [Petersen] has been more with us than anywhere else."
Titans coach Matthew Maynard included AB de Villiers, Morne Morkel and Jacques Rudolph in their 14-man squad on Friday.
He left out pace bowler Marchant de Lange, however, after suggesting earlier in the week that some of their Proteas may need to be rested.
Coming off a stunning semi-final super-over victory against the Knights last week, the Titans will look to carry that momentum into the final.
"A lot of the players have tasted success, and with other guys it's their first taste of a final so there's a lovely balance between the two," Maynard said.
Conversely, the Johannesburg outfit qualified automatically for the final, skipping the one-off semi-final after they finished top of the table.
The hosts have had a period off which could count against them.
"Consistency has been a factor, to keep a good group of players together and even the guys off the field who've trained hard and kept continuity throughout," Nosworthy said.
"Sunday is big for us. I think we've learnt a lesson from previous seasons where we qualified for the Champions League and rode the honeymoon a touch too long.
"This year we're over the honeymoon, as of possibly Monday already.
"The boys got into training and we're looking to win a trophy on Sunday. That's our main objective."