Mumbai - India lost explosive opener Virender Sehwag before reaching 74-1 in their first innings at lunch in reply to the West Indies' 590 on the third day of the third and final Test on Thursday.
Left-handed Gautam Gambhir was unbeaten on 30 at the break and Rahul Dravid on one not out.
West Indies seamer Darren Sammy provided the breakthrough in his third over when he bowled Sehwag (37) with a delivery that cut in to surprise the batsman on an easy-paced track at the Wankhede Stadium in Mumbai.
Sehwag, who added 67 runs for the opening wicket with Gambhir, played some attractive shots during his cameo as he lofted Sammy over the covers for a six in the bowler's opening over. He also hit three fours in his 50-ball knock.
The West Indies earlier added 15 runs off 3.1 overs to their overnight total of 575-9 before off-spinner Ravichandran Ashwin bowled Devendra Bishoo (12) to finish with 5-156 for his second five-wicket haul in the debut Test series.
Debutant paceman Varun Aaron claimed three wickets, while paceman Ishant Sharma and left-arm spinner Pragyan Ojha took one wicket each.
Darren Bravo top-scored for the West Indies with 166, while Kirk Edwards (86), Kieran Powell (81), Kraigg Brathwaite (68), Adrian Barath (62) and Marlon Samuels (61) made half-centuries.
India lead 2-0 in the series after winning the opening Test in New Delhi by five wickets and the second match in Kolkata by an innings and 15 runs.