West Indies have made two changes, with Sulieman Benn dropped, after he was sent-off by Gayle in the previous match for failing to follow instructions, and Ravi Rampaul sidelined with a knee injury. Narsingh Deonarine and Jerome Taylor have replaced them.
The South Africans have also made two changes, with Morne Morkel rested and David Miller also sidelined with a knee injury, so Roelof van der Merwe and Mark Boucher have taken their places.
Cricket South Africa revealed on Twitter: Mark Boucher is playing today but not as a wicket keeper, it will be interesting to see how he does as a fielder.
The Proteas lead the five-match series 4-0, after they won the fourth ODI by seven wickets last Sunday at Windsor Park in Dominica, where they also won the third ODI by 67 runs last Friday.
South Africa also won the rain-affected first ODI by 66 runs, under the Duckworth-Lewis Method, two Saturdays ago at the Vivian Richards Cricket Ground in Antigua, where they also won the second ODI by 17 runs.
This match and the first Test of three between the two sides, as well as a tour match in between were shifted from Sabina Park in Jamaica following an outbreak of violence in sections of the capital Kingston.
Teams
West Indies - Chris Gayle, Dale Richards, Narsingh Deonarine, Shivnarine Chanderpaul, Danny Bravo, Kieron Pollard, Dwayne Bravo, Denesh Ramdin, David Bernard, Darren Sammy, Jerome Taylor.
South Africa - Graeme Smith, Hashim Amla, Jacques Kallis, AB de Villiers, JP Duminy, Mark Boucher, Johan Botha, Roelof van der Merwe, Ryan McLaren, Lonwabo Tsotsobe, Charl Langeveldt.
Umpires: Norman Malcolm (WIS), Daryl Harper (AUS)
TV umpire: Goaland Greaves (WIS)
Match referee: Roshan Mahanama (SRI)
Reserve umpire: Clancy Mack (WIS)