Cape Town - The Proteas are underdogs in the first Test against Australia at the WACA in Perth on Thursday.
And, despite having won their last two Test series' on Australian soil in 2012/13 and 2008/09, Faf du Plessis' men are also not likely to emerge victorious over three matches this time around.
Local bookmakers Sportingbet have South Africa at 2/1 to win the first Test in Perth while the Aussies are favourites at 21/20.
The draw is the least likeliest scenario at 16/5.
The Aussies are also expected to triumph overall in the series, and are 7/10 favourites to do so while the Proteas are 5/2 outsiders to repeat the heroics of their last two tours Down Under.
A 1-1 or 0-0 series draw is on offer at 4/1.
The Proteas, who have lost series' to India and England over the last year, are currently ranked fifth in the world while Australia are third.
Thursday's match gets underway at 04:30 (SA time).