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The match was reduced to 42 overs a side after rain delayed the start by two-and-a-half hours.
With South African captain AB de Villiers being rested, Hashim Amla skippered the side. Amla was rested from the fourth match, which the West Indies won by one wicket in Port Elizabeth on Sunday.
Wicketkeeper-batsman Quinton de Kock was playing his first match of the series after making a faster-than-expected recovery from an ankle injury, while fast bowler Marchant de Lange came in for Morne Morkel.
Narsingh Deonarine replaced Leon Johnson in the West Indies team.
South Africa lead the series 3-1.
Teams:
South Africa: Hashim Amla (captain), Quinton de Kock (wkt), Faf du Plessis, Rilee Rossouw, David Miller, JP Duminy, Farhaan Behardien, Wayne Parnell, Aaron Phangiso, Kyle Abbott, Marchant de Lange
West Indies: Jason Holder (captain), Dwayne Smith, Chris Gayle, Narsingh Deonarine, Marlon Samuels, Denesh Ramdin (wkt), Jonathan Carter, Andre Russell, Darren Sammy, Carlos Brathwaite, Sheldon Cottrell
Umpires: Johan Cloete (RSA), Sundaram Ravi (IND)
TV umpire: Steve Davis (AUS),
Match referee: Chris Broad (ENG)
