LIVE SCORING: SA v Australia
Both players have been struggling with chronic injuries over the course of the series, which also involved Zimbabwe, with Morkel aggravating a rotator cuff tear in his right shoulder and Duminy battling with a left knee problem.
However, the pair successfully completed their fitness tests, leaving South Africa to make just one change to their side with leg spinner Imran Tahir coming in for batsman Rilee Rossouw.
South Africa captain AB de Villiers won the toss and opted to bowl first under sunny skies, meaning his side will chase for the third successive game against Australia.
While South Africa won the first encounter by seven wickets, Australia clinched the second by 62 runs.
Australia also made one change, with James Faulkner replacing the ill Kane Richardson.
Teams:
South Africa:
Hashim Amla, Quinton de Kock, Faf du Plessis, AB de Villiers (captain), David Miller, Jean-Paul Duminy, Dale Steyn, Wayne Parnell, Aaron Phangiso, Imran Tahir, Morne Morkel
Australia:
Aaron Finch, Phillip Hughes, Steven Smith, Glenn Maxwell, George Bailey (captain), Mitchell Marsh, Brad Haddin (wicketkeeper), Mitchell Johnson, Mitchell Starc, James Faulkner, Nathan Lyon