On the back of their successful Australian tour, JP Duminy and Herschelle Gibbs will make their first domestic Pro20 appearances this season.
Duminy requires 52 runs to achieve 900 Pro20 runs, while Andrew Puttick needs one run to achieve 600 runs.
On the bowling front, Charl Langeveldt requires three-wickets to achieve his 40th wicket.
The Cobras are currently tied in third position with the Eagles on eight points.
Squad:
Herschelle Gibbs, Andrew Puttick, Henry Davids, Richard Levi, JP Duminy, Justin Ontong, Vernon Philander, Roger Telemachus, Rory Kleinveldt, Claude Henderson, Charl Langeveldt, Sybrand Engelbrecht, Stiaan Van Zyl.