Misbah returned to captain Pakistan after sitting out the tourists' 2-0 Twenty20 series win.
Opener Ahmed Shehzad retained his place at the top of the Pakistan batting lineup after successive half-centuries in the T20 games to start the tour. Seamer Junaid Khan was recalled to partner Mohammad Irfan in an otherwise spin-heavy Pakistan attack.
Zimbabwe left out seam bowler Shingirai Masakadza at Harare Sports Club.
Pakistan
has won four of its last five ODI series and put together a strong
recent run, winning in India and West Indies over the last 12 months.
Zimbabwe has lost five of its last six, starting with a 3-0 defeat by
Pakistan at home in 2011.
Zimbabwe was whitewashed 5-0 by India this month and apart from a 2-1 series win over Bangladesh in May, the southern Africans last won an ODI game in 2011.
Pakistan is No 6 in the ODI rankings, while Zimbabwe is No 10 ahead of only Ireland, Netherlands and Kenya.
Teams:
Zimbabwe: Brendan Taylor (captain), Vusi Sibanda, Hamilton Masakadza, Sean Williams, Timycen Maruma, Malcolm Waller, Elton Chigumbura, Prosper Utseya, Tinashe Panyangara, Tendai Chatara, Brian Vitori.
Pakistan: Misbah-ul-Haq (captain), Nasir Jamshed, Ahmed Shehzad, Mohammad Hafeez, Umar Amin, Sarfraz Ahmed, Shahid Afridi, Haris Sohail, Junaid Khan, Saeed Ajmal, Mohammad Irfan.